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GLP-1 weight loss:BCAA for muscle health
Feb 27,2025
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A 2024 study in JAMA revealed a startling side effect of GLP-1 weight loss: while typical weight loss involves a 25% muscle loss, those using semaglutide saw muscle loss jump to 40%. This muscle loss is linked to GLP-1 receptor activation, which may reduce protein synthesis and increase protein breakdown in skeletal muscles.
But here’s the good news: BCAA (Branched-Chain Amino Acids) can help! BCAA, including leucine, isoleucine, and valine, are key players in promoting muscle protein synthesis and preventing breakdown. They bypass liver metabolism and directly support muscle activity, making them a powerful tool in preserving muscle mass during weight loss.
For those using semaglutide, BCAA supplementation can significantly reduce muscle loss, ensuring a more effective and comprehensive weight management approach.
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